Disenchanted with the daily drudge of crushing rocks on a prison farm in Mississippi; the dapper; silver-tongued Ulysses Everett McGill (George Clooney; THE PERFECT STORM) busts loose. Except he's still shackled to his own chain-mates from the chain gang -- bad-tempered Pete (John Turturro; SUMMER OF SAM); and sweet; dimwitted Delmar (Tim Blake Nelson; HAMLET). With nothing to lose and buried loot to regain -- before it's lost forever in a flood -- the three embark on the adventure of a lifetime in this hilarious offbeat road picture. Populated with strange characters; including a blind prophet; sexy sirens; and a one-eyed Bible salesman (John Goodman; COYOTE UGLY); it's an odyssey filled with chases; close calls; near misses; and betrayal that will leave you laughing at every outrageous and surprising twist and turn.